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Sebastián Ayala-Ruano
I am a young researcher and freelance data scientist. I have worked in Bioinformatics and Cheminformatics for five years at various laboratories. My current research interests are devoted to Network Science and Machine Learning to study different biological phenomena. I am part of several research, open-science, and software development communities (ISCBSC, The Carpentries, Streamlit Creators, and Open Life Science). Moreover, I was involved in some initiatives to empower Bioinformatics in Ecuador and Latin America.
Education
MSc, Systems Biology
Maastricht University (UM)
Maastricht, the Netherlands
2024 - 2022
- Scholarship: UM Holland-High Potential Scholarship for students from outside the EU/EEA.
- GPA: 8.78/10 (Cum Laude) - best score of the Systems Biology 2024 class.
- Thesis: MicW2Graph: Building a knowledge graph of the wastewater treatment microbiome and its biological context - MaCSBio thesis award.
B.Eng., Biotechnology
Universidad San Francisco de Quito (USFQ)
Quito, Ecuador
2020 - 2016
- Minor: Software engineering.
- GPA: 3.78/4 (Magna Cum Laude) - second best score of the College of Biological and Environmental Sciences 2020 class.
Work Experience
Research Intern
Multi-omics Network Analytics Group - Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark
Copenhagen, Denmark
May. 2024 - Nov. 2023
- Investigated the microbiome of wastewater treatment to build MicW2Graph, an open-source knowledge graph that integrates metagenomic and metatranscriptomic information with their biological context, including biological processes, environmental features, chemical compounds, and additional metadata (See details here).
- Advisors: Alberto Santos Delgado, Martina Kutmon
Data Science Consultant
Universidad de Las Américas
Quito, Ecuador
Oct. 2022 - Apr. 2022
- Created a curated database of 50,000 herbarium records from tropical forest species of the Americas using web scraping and the Global Biodiversity Information Facility API.
- Developed machine learning classifiers to predict the phenological stages of the forest species using the herbarium records. These models can be used to design conservation strategies of the tropical forest species (See details here).
Research Assistant
Applied Signal Processing and Machine Learning Research Group - USFQ
Quito, Ecuador
2021
- Created a method based on network science and similarity searching to explore the chemical space of antiparasitic peptides and discover new drugs (See details here).
- Advisors: Yovani Marrero-Ponce, Noel Pérez Pérez
Research Intern
Computational and Theoretical Chemistry Group - USFQ
Quito, Ecuador
2020 - 2017
- Identified binding specificity between repressor proteins and a transcriptional factor associated with the jasmonic acid pathway in Arabidopsis thaliana through molecular dynamics simulations and machine learning algorithms (See details here).
- Advisor: Miguel Angel Méndez Silva
Research Intern
Bio-Chemoinformatics Group - Universidad de Las Américas
Quito, Ecuador
2020 - 2018
- Understood the impact of horizontal gene transfer in the genome of Streptomyces clavuligerus using phylogenetics, and other bioinformatics tools (See details here).
- Proposed molecular mimicry between Zika envelope protein and human neuronal proteins through molecular dynamics and protein-protein interaction networks.
- Advisors: Vinicio Armijos, Yunierkis Perez
Research Intern
Tumor Metabolism and Therapeutic Oncology Laboratory - Gwangju Institute of Science and Technology
Gwangju, South Korea
2019
- Performed density functional theory and molecular dynamics simulations to understand the impact of a mutation in the ZN domain of the CRBN protein (See details here).
- Advisors: Miguel Angel Méndez Silva, Steve K. Cho
Teaching Experience
Co-organizer and co-instructor of a Bioinformatics boot camp
Virtual event
2021
- I designed and taught the course material.
- This course covered the basics of Linux, terminal usage, text and file processing command line tools, Bash/AWK scripting with applications in Bioinformatics, and Git/GitHub.
Undergraduate Teaching Assistant
Learning Center - USFQ
Virtual events
2020
- Provided online mentorship of Biotechnology, Mathematics, and Engineering subjects to undergraduate students.
Undergraduate Teaching Assistant
General Biology Laboratory - USFQ
Quito, Ecuador
2018 - 2016
- Graded reports, tests, and other homework from the course.
- Provided feedback and guidance to undergraduate students in topics of the course.
Publications
Peer reviewed journal articles
- Aguilera-Mendoza, L., Ayala-Ruano, S.*, Martinez-Rios, F., Chavez, E., García-Jacas, C. R., Brizuela, C. A., & Marrero-Ponce, Y. (2023). StarPep Toolbox: an open-source software to assist chemical space analysis of bioactive peptides and their functions using complex networks. Bioinformatics, 39 (8), btad506. doi: doi.org/10.1093/bioinformatics/btad506
- Ayala-Ruano S., Marrero-Ponce Y., Aguilera‑Mendoza L., Pérez N., Agüero-Chapin G., Antunes A., Aguilar A. (2022). Network Science and Group Fusion Similarity-Based Searching to Explore the Chemical Space of Antiparasitic Peptides. ACS omega, 7 (50), 46012-46036. doi: doi.org/10.1021/acsomega.2c03398. Preprint: doi.org/10.26434/chemrxiv-2021-tgv69-v2.
- Oña-Chuquimarca, S., Ayala-Ruano, S., Goossens, Pauwels, L., Goossens, A., Leon-Reyes, A., & Méndez, M. A (2020). The molecular basis of JAZ-MYC coupling, a protein-protein interface essential for plant response to stressors. Frontiers in Plant Science, 11, 1139. doi: 10.3389/fpls.2020.01139. This article was included in the Frontiers in Plant Science 2020 highlights e-book. doi: 10.3389/978-2-88966-723-9.
- Ayala‐Ruano, S., Santander‐Gordón, D., Tejera, E., Perez‐Castillo, Y., & Armijos-Jaramillo, V. (2019). A putative antimicrobial peptide from Hymenoptera in the megaplasmid pSCL4 of Streptomyces clavuligerus ATCC 27064 reveals a singular case of horizontal gene transfer with potential applications. Ecology and Evolution, 9 (5), 2602-2614. doi: 10.1002/ece3.4924.
Editorial journal articles
- Osorio-Mogollon C, Grentzinger V, Olguin-Orellana GJ, Ayala-Ruano S., et al. (2023). ISCB Student Council Symposium 2021, a virtual global venue: challenges and lessons learned. F1000Research, 12(50). doi: 10.12688/f1000research.129945.1.
- Ayala-Ruano S.*, Hernandez, F., Ortega, A., Infante, D., Carrascal, D., Sánchez-Luquez, K., & Puche-Quiñonez, R. (2022). Highlights of the 1st Ecuadorian-Venezuelan Symposium of Young Researchers in Bioinformatics (1SEVJIB). F1000Research, 11(1086), 1086. doi: 10.12688/f1000research.125381.1.
- Castillo-Vilcahuaman, C., Valdivia C., Osorio-Mogollón C., Silva-Andrade, C., Puche, R., Ayala‐Ruano, S., Cuesta-Astroz, Y., Parra, G (2020). 4th ISCB Latin American Student Council Symposium: a virtual and inclusive experience during COVID19 times. F1000Research, 9. doi: 10.12688/f1000research.28330.1.
Others
Ayala-Ruano, S.*, & Zurita, J. (2021). HerrCompBioinfo: un recurso educativo de código abierto de herramientas computacionales para entusiastas de la Bioinformática. doi: doi.org/10.5281/zenodo.5748335
*co-first author
Selected presentations
- Contributing Guidelines and Codes of Conduct for Open Projects. (2022). Expert talk. 6th cohort of Open Life Science (See details here).
- Exploring the chemical space of antiparasitic peptides and discovery of new promising leads through a novel approach based on network science and similarity searching. (2022). Oral presentation. International Society for Computational Biology Student Council Webinar series (See details here).
- HerrCompBioinfo: An open-source educational resource of computational tools for Bioinformatics enthusiasts written in Spanish. (2022). Oral presentation. 4th cohort of Open Life Science Graduation (See details here).
- The molecular basis of JAZ-MYC coupling, a protein-protein interface essential for plant response to stressors. (2021). Oral presentation. 6th Brazilian Student Council Symposium: Omics and Data Science (See details here).
- In silico detection of horizontal gene transfer in Streptomyces clavuligerus. (2020). Oral presentation. International Society for Computational Biology Student Council Webinar series (See details here).
- Structural changes due to a mutation in Cereblon might be a cause for intellectual disability. (2019). Poster presentation. Global Intern Program - Gwangju Institute of Science and Technology (See details here).
Honors and Awards
MaCSBio Thesis Award
Maastricht University
Maatricht, the Netherlands
2024
- MaCSBio selects one of the graduating MSc System Biology students based on thesis defense quality, quality of the written thesis, scientific merit of the written thesis, and academic records.
Visit Grant
Copenhagen, Denmark
2024
- This grant covered the travel and accomodation expenses for my MSc thesis internship.
Cum Laude Graduation Distinction
Maastricht University
Maatricht, the Netherlands
2024 - 2022
- This award recognizes students who have a GPA of 8/10 or higher.
UM Holland-High Potential Scholarship
Maastricht University
Maatricht, the Netherlands
2022
- The UM Holland-High Potential Scholarship programme offers 24 full scholarships of € 30,000 (including tuition fee waiver and monthly stipend) each academic year for highly talented students from outside the European Union (EU) who have been admitted to a master’s programme at UM.
Best oral presentation award
6th Brazilian Student Council Symposium: Omics and Data Science
Virtual event
2021
“For more data on labor informality” Innovation Challenge Award
Datalat, PNUD Ecuador, UN Women Ecuador, and the International Labour Organization
Virtual event
2021
- This competition searched for a technological solution to collect labor informality data in Ecuador. There were 39 proposals from 80 interdisciplinary teams (See details about the challenge here).
Chancellor’s Honor List and Magna Cum Laude Graduation Distinction
Universidad San Francisco de Quito
Quito, Ecuador
2020 - 2016
- These awards recognize students who have a GPA of 3.7/4 or higher.
Third HPC Summer School Colombia: Bio and Data Science scholarship
CyberColombia
Virtual event
2020
- The scholarship covered registration expenses for the event.
2nd RSG-Colombia Symposium travel award
RSG Colombia
Ibagué, Colombia
2019
- This award covered the travel expenses to attend the event.
Global Intern Program Scholarship
Gwangju Institute of Science and Technology
Gwangju, South Korea
2019
- The GIP awarded students with accommodation and a monthly stipend to cover living expenses for eight weeks. During this time, we were involved in a research project and received valuable training and mentoring.
Leadership and Service
Streamlit creators program
Virtual
Current - 2022
- I have created several web applications with the Streamlit Python package and became part of the community of creators.
Open Life Science (OLS) program
Virtual
Current - 2021
- Leader of the HerrCompBioinfo project during the 4th cohort of the OLS program. We created an open-source educational resource of computational tools for Bioinformatics enthusiasts written in Spanish. Also, I learned how to create and manage open science and open source projects.
- I mentored a group in the 5th cohort of the OLS program to create a computer vision-based tool to improve cancer diagnosis in Cameroon. See details about this project here.
- I gave a talk about contributing guidelines and codes of conduct for open projects in the 6th cohort of OLS program.
Regional Student Group (RSG) Ecuador
International Society for Computational Biology Student Council
Virtual
2023 - 2020
- Co-founder and current president of the RSG Ecuador. This group aims to create a long-lasting community of students and researchers residing in Ecuador that work on Bioinformatics.
- Co-chair of the 1st Ecuadorian-Venezuelan Symposium of Young Bioinformatics Researchers.
- Fellowship committee chair of the 17th Student Council Symposium.
- Contributed to the program and fellowships committees of the 4th ISCB Latin American Student Council Symposium.
Saturdays.AI Quito 2021
Virtual event
2021
- Led my group project, which was an early plant disease detector based on convolutional neural networks, trained to recognize two types of maize infectious diseases.(See details here).
Note: I have developed other personal projects related to data science, machine learning, bioinformatics, and other topics (See details here).